Spore
The creator of the Sims, Will Wright, has been working on the game spore for what seems to be forever. I hate to disappoint you people, but the promising game is probably going to be delayed yet again. The game is predicted to not arrive till the second half of ‘08.
This game seems to be very promising. In this game, players begin as a single-cell organism at a microscopic level (no you are not an egg). You continue to evolve to the creature phase. You are one organism fighting for survival. As the game goes on, you enter the tribe phase. In this phase, you lead a tribe of your organisms. The next level is the civilization level. The point of this level is to conquer your planet. Finally, you enter the space phase, which ends with you conquering the galaxy.